Moyi Li
Associate Professor、PhD Supervisor
Email: moyili@seu.edu.cn
Office Location: Room A405, Huichuan Building, Jiangbei Campus
EDUCATION & RESEARCH EXPERIENCE
1996. 09 — 2000. 06 Bachelor of Science，Microbiology，Huazhong Agricultural University
2000. 09 — 2003.06 Master of Engineering，Biochemical Engineering，Huazhong University of Science and Technology
2003. 08 — 2008.05 Ph.D.，Plant Pathology，University of Florida
2009. 01 — 2013.07 Postdoctoral Associate，University of Florida
2014. 01 — 2016.02 Postdoctoral Associate，Institute of Life Sciences, Southeast University
2016. 02 — 2019.11 Associate Professor，Institute of Life Sciences, Southeast University
2019. 12 — present Associate Professor，School of Life Sciences and Technology, Southeast University
RESEARCH INTERESTS
Neuropsychiatric disorders, such as autism spectrum disorders (ASD) and related heritable neurological diseases, are increasingly prevalent and have a significant impact on patients' quality of life, especially their lifelong social dysfunction. The pathogenesis of ASD is complex, and it relies on the dual effects of genetic and environmental factors. Currently, there are still no effective targeted treatments for ASD and related heritable neurological diseases. We aim to answer questions from the following aspects and provide clues for the pathological mechanisms and personalized treatment of these diseases: What and How the genetic and environmental factors cause synaptic and neurological aberrance at the molecular/ cellular/ neural circuit levels in ASD and related diseases, and how to correct them especially social defects?
REPRESENTATIVE PUBLICATIONS
* co-first author; # corresponding author
1.Peng S*, Li M*#, Yang X, Xie W. The neural basis of affective empathy: What is known from rodents. Neuropharmacology. 2025 May 15; 269:110347.
2.Peng S, Yang X, Meng S, Liu F, Lv Y, Yang H, Kong Y, Xie W, Li M#. Dual circuits originating from the ventral hippocampus independently facilitate affective empathy. Cell Rep. 2024 Jun 25;43(6):114277. doi: 10.1016/j.celrep.2024.114277.
3.Sun Y, Li M#, Geng J, Meng S, Tu R, Zhuang Y, Sun M, Rui M, Ou M, Xing G, Johnson TK, Xie W#. Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila. Commun Biol. 2023 Oct 18;6(1):1056. doi: 10.1038/s42003-023-05428-3.
4.Peng S, Gu W, Zhu W, Zhuang Y, Yang X, Lv Y, Meng S,Xie W, Li M#. A new AAV tool for highly preferentially targeting hippocampal CA2. (2023) Mol Brain. Jun 11;16(1):50. doi: 10.1186/s13041-023-01038-6.
5.Li M*#, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W#. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477.
6.Xing G*, Li M*, Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W. Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457
7.Lee KY*, Li M*, Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900
8.Li M., Liang X., and Rollins J.A. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420
9.Li M. and Rollins J.A. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538
10.Li M. and Rollins J.A. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43