Jingjing Wang Professor
E-mail: jingjing.wang@seu.edu.cn
Office address: Rm B301-2, Hui-Chuang Building, Southeast University Jiangbei Campus
Education and Research experience
2024.06-present Professor, Southeast University
2023.05-2024.05 Research Associate, Northwestern University
2021.01-2023.04 Postdoctoral Fellow, Northwestern University
2016.05-2020.12 Postdoctoral Research Associate, University of Colorado Boulder
2016.01 Ph.D., University of Chinese Academy of Sciences
Research focuses : Non-coding RNAs modulating stem cell fate to control development and regeneration of skin and its appendages
Skin is the outermost tissue of the human body. In addition to the epidermis and dermis, the skin contains appendages such as hair follicles and sebaceous glands, which supplement its functions. The development, maintenance, and regeneration of the skin and its appendages depend on the precise regulation of stem cell fate within the skin. Abnormal stem cell fate decisions can lead to skin diseases, including hereditary skin disorders, hair loss, melanoma, and others.
Our research focuses on elucidating the mechanisms by which non-coding RNAs modulate stem cell fate to control the development and regeneration of the skin and its appendages. We employ genetic, cellular, biochemical, transcriptomic, and intravital imaging approaches in our studies. Concurrently, we are investigating the role of alterations in mechanical properties in hair loss and skin diseases.
Publication
1.Jingjing Wang, Chaoyu Fu, Sophie Chang, Christopher Stephens, Haimin Li, Dongmei Wang,Yuheng Fu, Kathleen J. Green, Jie Yan and Rui Yi. PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence. Science Advances,Vol 11, Issue 22, 2025.
2. Jingjing Wang, Yuheng Fu, Joshua A. Broussard, Ritusree Biswas, Avinanda Banerjee, Zhihai Zhao, Wenmao Huang, Dongmei Wang, Glen Bjerke, Srikala Raghavan, Jie Yan, Kathleen J. Green & Rui Yi. MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells. PNAS, May 22, 2023120 (22) e2220635120.
3. Chi Zhang, Dongmei Wang, Jingjing Wang, Li Wang, Wenli Qiu, Tsutomu Kume, Robin Dowell & Rui Yi. Escape of hair follicle stem cells causes stem cell exhaustion during aging. Nature Aging 1, 889–903 (2021)
4. Jingjing Wang, Jerome E. Lee, Kent Riemondy, Yang Yu, Steven M. Marquez, Eric C. Lai & Rui Yi. XPO5 promotes primary miRNA processing independently of RanGTP. Nature Communications 11, 1845 (2020)
5. Chen Cui#, Jing-Jing Wang#, Jian-Hua Zhao#, Yuan-Yuan Fang, Xiang-Feng He, Hui-Shan Guo & Cheng-Guo Duan. A Brassica miRNA Regulates Plant Growth and Immunity through Distinct Modes of Action. Molecular Plant. 2020 Feb 3;13(2):231-245. # These authors contributed equally to this work.
6. Jing-Jing Wang & Hui-Shan Guo. Cleavage of INDOLE-3-ACETIC ACID INDUCIBLE28 mRNA by microRNA847 upregulates Auxin signaling to modulate cell proliferation and lateral organ growth in Arabidopsis. The Plant Cell (online, Vol. 27: 574–590, March 2015).